Induction of IL-22 protein and IL-22-producing cells in rainbow trout Oncorhynchus mykiss

Rainbow Trout, Oncorhynchus mykiss

Rainbow trout are classified as Oncorhynchus mykiss, and as such belong to the same genus as Pacific salmon, and to the family Salmonidae, which includes Atlantic salmon (Salmo salar), various trout (Salvelinus sp.), Arctic char (Salvelinus alpinus), Arctic grayling (Thymallus arcticus) and whitefish (Coregonus sp.). Rainbow trout are native to areas around the North Pacific Ocean, from souther...

IL 22 ( interleukin 22 )

Induction of Interleukin-22 (IL-22) production in CD4+ T Cells by IL-17A Secreted from CpG-Stimulated Keratinocytes

BACKGROUND Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that keratinocytes play an important role in the pathogenesis of psoriasis. OBJECTIVE To investigate the potential role of keratinocytes, we examined whether TLR9 ligand CpG ind...

Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.

IL-22 is a cytokine that acts mainly on epithelial cells. In the skin, it mediates keratinocyte proliferation and epidermal hyperplasia and is thought to play a central role in inflammatory diseases with marked epidermal acanthosis, such as psoriasis. Although IL-22 was initially considered a Th17 cytokine, increasing evidence suggests that T helper cells can produce IL-22 even without IL-17 ex...

IL-22 vs. IL-22: The Tissue Matters

IL-22 is a cytokine recently discovered to be produced by TH17 cells. Its receptor is expressed in the skin, liver, the digestive and the respiratory tract where IL-22 conveys signals of the immune system directly to the tissue. IL-22 is involved in the host defense against extracellular pathogens as well as in autoimmune inflammatory diseases and exerts, depending on the tissue and inflammator...